Anne Harris's paintings and drawings have been exhibited at venues ranging from Alexandre Gallery, DC Moore Gallery, and Nielsen Gallery to the National Portrait Gallery at the Smithsonian Institute, The Portland Museum of Art, the California Center for Contemporary Art, and the North Dakota Museum of Art. In addition, her work is in such public collections as The Fogg Museum at Harvard, The Yale University Art Gallery, and The New York Public Library. Grants and awards include a Guggenheim Foundation Fellowship and an NEA Individual Artists Fellowship.

Harris is an Associate Professor in the Painting and Drawing Department at The School of the Art Institute of Chicago. She also is Chair of the Exhibition Committee at the Riverside Arts Center and has curated numerous exhibitions there. She also is the originator of The Mind's I—an expanding traveling drawing project she does with other artists, which is designed to investigate the complexities of perception and self-perception. Mind's I drawing events and exhibitions have taken place across the U.S. and internationally.